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Home/Research/Salvia Divinorum/Medicinal Chemistry & Drug Development

Salvia Divinorum for Medicinal Chemistry & Drug Development

5 papers and 0 clinical trials exploring salvia divinorum as a treatment for medicinal chemistry & drug development.

CompoundDiterpenoid

Salvia Divinorum

A specialized plant species that produces salvinorin A, a potent and selective kappa-opioid agonist with intense, short-lived effects.

Full Salvia Divinorum profile
IndicationOver 300 million people worldwide experience depression, with many also suffering from related anxiety disorders.

Medicinal Chemistry & Drug Development

Medicinal chemistry plays a crucial role in the development of novel psychedelic compounds, focusing on their molecular structures and interactions. Researchers utilise innovative methods to enhance safety and efficacy in psychedelic substances.

Full Medicinal Chemistry & Drug Development profile

Academic Research

5 papers
Paywallmeta

DARK Classics in Chemical Neuroscience: Salvinorin A

This review (2020) discusses the history, chemistry, pharmacology, and other aspects of salvinorin A, the main bioactive compound in the drug Salvia divinorum.

Published
November 9, 2020
Journal
ACS Chemical Neuroscience
Authors
Hernández-Alvarado, R. B., Madariaga-Mazón, A., Ortega, A., Martinez-Mayorga, K.
Open Accessmeta

A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics

This review (2016) examines the psychoactive properties and therapeutic potential of Salvinorin A, a kappa-opioid receptor agonist that is the bioactive constituent of the indigenous plant Salvia divinorum. Next to highly potent psychoactive properties as a dissociative hallucinogen, preliminary scientific evidence also indicates it may have broad-range therapeutic applications for treating addiction, inflammation, pain, and depression.

Published
May 1, 2017
Journal
Phytochemistry
Authors
Cruz, A. P. M., Domingos, S., Gallardo, E., Martinho, A.
Open Accessindividual

Time course of pharmacokinetic and hormonal effects of inhaled high-dose salvinorin A in humans

High‑dose inhaled salvinorin A produced peak plasma concentrations within 2 minutes followed by a rapid decline, and these plasma levels were significantly correlated with participant- and monitor-rated drug effects—this is the first human study to demonstrate a direct pharmacokinetic–effect relationship. Prolactin rose from 5 minutes and peaked at 15 minutes while cortisol responses were inconsistent, and the results confirm the efficacy of the vapour inhalation technique.

Published
February 15, 2016
Journal
Journal of Psychopharmacology
Authors
Johnson, M. W., Maclean, K. A., Caspers, M. J., Prisinzano, T. E., Griffiths, R. R.
Paywallindividual

Synthesis and κ-opioid receptor activity of furan-substituted salvinorin A analogues

This animal study (n=12) synthesized several different furan-substituted salvinorin A analogs and identified three potent variants which reduced drug-induced reinstatement of cocaine-seeking behavior, without producing the sedation observed with other κ-opioid agonists.

Published
December 9, 2014
Journal
Journal of Medicinal Chemistry
Authors
Riley, A. P., Groer, C. E., Young, D., Ewald, A. W., Kivell, B. M., Prisinzano, T. E.
Open Accessindividual

Dose-related Behavioral, Subjective, Endocrine and Psychophysiological Effects Of the Kappa Opioid Agonist Salvinorin A in Humans

This double-blind, randomised controlled trial (n=10) assessed the behavioural, subjective, cognitive, psychophysiological and endocrine effects of Salvia divinorum (0, 8 and 12 mg) in healthy participants. Salvia produced psychotomimetic effects and perceptual alterations, including dissociative and somaesthetic effects, increased plasma cortisol and prolactin and reduced resting EEG spectral power, but did not produce euphoria, cognitive deficits or changes in vital signs. Overall, Salvia was well tolerated.

Published
November 1, 2012
Journal
Biological Psychiatry
Authors
Ranganathan, M., Schnakenberg, A., Skosnik, P. D., Cohen, B., Pittman, B. P., Sewell, R. A., D’Souza, D. C.

Clinical Trials

0 trials

No clinical trials have been tagged with both Salvia Divinorum and Medicinal Chemistry & Drug Development yet.

Trials are continuously being added as new studies are registered.

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Search all Salvia Divinorum papers Search all Medicinal Chemistry & Drug Development trials Full Salvia Divinorum profile Full Medicinal Chemistry & Drug Development profile