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Home/Research/Salvia Divinorum/Neuroimaging & Brain Measures

Salvia Divinorum for Neuroimaging & Brain Measures

4 papers and 0 clinical trials exploring salvia divinorum as a treatment for neuroimaging & brain measures.

CompoundDiterpenoid

Salvia Divinorum

A specialized plant species that produces salvinorin A, a potent and selective kappa-opioid agonist with intense, short-lived effects.

Full Salvia Divinorum profile
IndicationApproximately 264 million people globally suffer from depression, with PTSD affecting around 8 million adults in the United States each year.

Neuroimaging & Brain Measures

Recent advances in neuroimaging have shed light on the neurobiological mechanisms underlying the effects of psychedelics, particularly in the treatment of mental health disorders such as depression and PTSD. Studies involving compounds like psilocybin and MDMA have demonstrated significant changes in brain activity associated with therapeutic outcomes.

Full Neuroimaging & Brain Measures profile

Academic Research

4 papers
Paywallindividual

Acute Effects of Hallucinogens on Functional Connectivity: Psilocybin and Salvinorin-A

This fMRI study explores the effects of psilocybin (a serotonergic psychedelic) and Salvinorin-A (a kappa-opioid receptor agonist) on resting-state functional connectivity (FC) in nonhuman primates. It reveals both drugs influence FC around the thalamus, claustrum, prefrontal cortex (PFC), and default mode network (DMN), with similarities and differences noted between them.

Published
June 25, 2024
Journal
ACS Chemical Neuroscience
Authors
Bagdasarian, F. A., Hansen, H. D., Chen, J., Yoo, C. H., Placzek, M. S., Hooker, J. M., Wey, H. Y.
Paywallindividual

The kappa opioid receptor and the sleep of reason: Cortico-subcortical imbalance following salvinorin-A

Acute administration of salvinorin-A, a highly selective kappa opioid receptor agonist, produced dramatic dissociative psychotomimetic effects without dysphoria and revealed a cortico–subcortical imbalance. Neurophysiologically this was reflected by widespread cortical hypoperfusion and reduced cortical EEG alpha (with increased delta and gamma) alongside increased blood flow in medial temporal regions (amygdala, hippocampal gyrus) and the cerebellum.

Published
September 19, 2021
Journal
International Journal of Neuropsychopharmacology
Authors
Ona, G., Sampedro, F., Romero, S., Valle, M., Camacho, V., Migliorelli, C., Mañanas, M. Á., Antonijoan, R. M., Puntes, M., Coimbra, J., Ballester, M. R., Garrido H Msc, M., Riba, J.
Open Accessindividual

The Acute Effects of the Atypical Dissociative Hallucinogen Salvinorin A on Functional Connectivity in the Human Brain

In a placebo-controlled fMRI study, acute inhaled salvinorin A altered human functional connectivity — most prominently attenuating default mode network connectivity during peak effects, reducing brainwide dynamic functional connectivity and (non-significantly) increasing entropic connectivity. Dynamic-connectivity patterns, especially early in the scan, reliably classified the salvinorin A state, and the overall connectivity profile resembles that reported for other hallucinogens.

Published
October 2, 2020
Journal
Scientific Reports
Authors
Doss, M. K., May, D. G., Johnson, M. W., Clifton, J. M., Hedrick, S. L., Prisinzano, T. E., Griffiths, R. R., Barrett, F. S.
Open Accessindividual

Dose-related Behavioral, Subjective, Endocrine and Psychophysiological Effects Of the Kappa Opioid Agonist Salvinorin A in Humans

This double-blind, randomised controlled trial (n=10) assessed the behavioural, subjective, cognitive, psychophysiological and endocrine effects of Salvia divinorum (0, 8 and 12 mg) in healthy participants. Salvia produced psychotomimetic effects and perceptual alterations, including dissociative and somaesthetic effects, increased plasma cortisol and prolactin and reduced resting EEG spectral power, but did not produce euphoria, cognitive deficits or changes in vital signs. Overall, Salvia was well tolerated.

Published
November 1, 2012
Journal
Biological Psychiatry
Authors
Ranganathan, M., Schnakenberg, A., Skosnik, P. D., Cohen, B., Pittman, B. P., Sewell, R. A., D’Souza, D. C.

Clinical Trials

0 trials

No clinical trials have been tagged with both Salvia Divinorum and Neuroimaging & Brain Measures yet.

Trials are continuously being added as new studies are registered.

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Search all Salvia Divinorum papers Search all Neuroimaging & Brain Measures trials Full Salvia Divinorum profile Full Neuroimaging & Brain Measures profile