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Home/Research/Salvia Divinorum/Palliative & End-of-Life Distress

Salvia Divinorum for Palliative & End-of-Life Distress

1 paper and 0 clinical trials exploring salvia divinorum as a treatment for palliative & end-of-life distress.

CompoundDiterpenoid

Salvia Divinorum

A specialized plant species that produces salvinorin A, a potent and selective kappa-opioid agonist with intense, short-lived effects.

Full Salvia Divinorum profile
IndicationApproximately 40% of patients with terminal illnesses report significant distress at the end of life.

Palliative & End-of-Life Distress

Palliative and end-of-life distress represents a significant psychosocial challenge faced by patients with life-limiting illnesses, significantly impacting quality of life. Recent research suggests that psychedelic compounds, particularly psilocybin, may offer promising therapeutic benefits in alleviating existential distress and improving psychological well-being in these patients.

Full Palliative & End-of-Life Distress profile

Academic Research

1 paper
Open Accessindividual

Neurochemical models of near-death experiences: A large-scale study based on the semantic similarity of written reports

This large-scale data-analytic study compared the semantic similarity of psychoactive trip reports (n≈15,000) and narrative accounts Near-Death Experiences (n=625), and found that ketamine (followed by salvinorin A and DMT) bared the most resemblance to the experience of 'dying'. The authors speculate that a ketamine model of Near-Death Experiences may indicate a neuroprotective function of endogenous NMDA antagonists released in the proximity of death.

Published
March 1, 2019
Journal
Consciousness and Cognition
Authors
Martial, C., Cassol, H., Charland-Verville, V, Erowid, E., Pallavicini, C., Sanz, C., Vivo, R. M, Zamberlan, F., Erowid, F., Laureys, S., Greyson, B., Tagliazucchi, E.

Clinical Trials

0 trials

No clinical trials have been tagged with both Salvia Divinorum and Palliative & End-of-Life Distress yet.

Trials are continuously being added as new studies are registered.

Explore further

Search all Salvia Divinorum papers Search all Palliative & End-of-Life Distress trials Full Salvia Divinorum profile Full Palliative & End-of-Life Distress profile