Federal University of Rio Grande do Norte (UFRN)

Safety, Tolerability and Antidepressant Effects of DMT in Patients With Depression

Start Date

October 9, 2023

Compounds

DMT

Safety and Tolerability of DMT in Healthy Adults

Start Date

April 26, 2023

Compounds

DMT, Placebo

Antidepressant Effects of Ayahuasca: a Randomized Placebo Controlled Trial in Treatment Resistant Depression

Start Date

February 1, 2014

Compounds

Ayahuasca, Placebo

Clinical Study of DMT in Healthy Adults

Start Date

June 1, 2022

Compounds

DMT

Naturalistic Study of Ketamine in the Treatment of Depression

Start Date

May 1, 2021

Compounds

Ketamine

The Impact of Ayahuasca on Suicidality: Results From a Randomized Controlled Trial.

This secondary analysis of a double-blind, parallel-arm, randomised placebo-controlled trial (n=29) investigates the impact of ayahuasca on suicidality (SI) in individuals with treatment-resistant depression (TRD). It found that ayahuasca may show potential as a fast-acting and innovative intervention for SI, but didn't find significant results (only a trend with a large effect size). This is the first study to investigate the use of ayahuasca for SI.

Published

November 19, 2019

Journal

Frontiers in Pharmacology

Authors

Araújo, D. B., Zeifman, R. J., Palhano-Fontes, F., Hallak, J. E., Arcoverde, E., Maia-de-Oliveira, J. P.