Clinical Study of DMT in Healthy Adults

This Phase I sequential dose-escalation study evaluates the acute and subacute effects of inhaled N,N-dimethyltryptamine in healthy volunteers. Participants are enrolled in five cohorts, each receiving two inhaled doses in a fixed ascending order on the same day with a 2-hour interval.

Dosing is administered via a vaporizer device; cohort dose pairs range from 5→20 mg to 15→60 mg. Outcomes include safety and tolerability measures and assessment of acute and subacute subjective effects.

No structured psychological support is provided as part of the dosing sessions.