Rett Syndrome Research Trust

The Rett Syndrome Research Trust (RSRT) is a US-based nonprofit dedicated to curing Rett syndrome (RTT) that funded, held the IND for, and oversaw a randomized double-blind placebo-controlled crossover trial of oral ketamine in girls aged 6-12 with RTT; the study confirmed safety and tolerability and demonstrated EEG evidence of NMDA receptor target engagement, supporting further trials with longer duration or higher doses.