A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine

Primary objective is to investigate whether BI 409306, BI 425809 and lamotrigine attenuate ketamine-induced cognitive deficits in healthy male participants.

Randomized, triple-masked, double-dummy three-treatment period crossover with matched placebo; participants receive each treatment in separate periods (total n=40, tablets/film-coated tablets). Cognitive assessments performed after ketamine challenge to measure memory and related outcomes.