A Study to Decrease Suicidal Thinking Using Ketamine

Background: Sub-anesthetic IV ketamine has shown rapid reductions in suicidal ideation in prior studies; this trial tests a single 0.2 mg/kg IV bolus in military patients hospitalised for suicidal thinking.

Design: Randomised, double-blind, parallel-group comparison of ketamine versus placebo with acute monitoring for 240 minutes post-dose and follow-up assessments at next day, discharge, 2 weeks and 10 weeks; safety surveillance via electronic medical record for up to one year.