Abuse Liability and Human Pharmacology of Mephedrone

Randomised, double-blind, crossover pharmacology study in healthy male volunteers (n=12) comparing single oral mephedrone 200 mg, MDMA 100 mg, and lactose placebo to assess subjective, cardiovascular, and pharmacokinetic effects.

Eligibility required prior recreational use of stimulants, normal labs/ECG, and CYP2D6 extensive or intermediate metaboliser phenotype; outcomes include abuse-liability measures, physiological monitoring and safety assessments.