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Acute Dose-dependent Effects of DMT-bolus Applications in Healthy Subjects (DMT BDR-Study) (DMT BDR)

Not yet recruitingRegisteredCTG

Randomized crossover, Phase I healthy volunteer study (n=36) testing IV DMT boluses (5–25 mg range, with placebo) to establish dose–response for subjective and autonomic effects.

Details

This randomized, crossover study in healthy volunteers uses intravenous DMT bolus doses (5, 10, 15, 20 mg; escalation arm includes 25 mg) and saline placebo to map dose–response relationships for subjective experience and autonomic effects.

Bolus applications are given as 45-second IV injections separated by one hour; outcomes include subjective ratings and physiological measures (blood pressure, heart rate, autonomic parameters).

Topics:Healthy Volunteers

Registry

Registry linkNCT05695495