Acute Dose-dependent Effects of DMT in Healthy Subjects: A Placebo-controlled Cross-over Study (DMT DR)

Randomized, double-blind, placebo-controlled 5-period crossover in healthy volunteers (n=24) testing IV DMT at 0.6, 1.2, 1.8 and 2.4 mg/min with a placebo arm; a sixth session permits patient-guided titration.

Primary aim is to characterise dose–response relationships for subjective and autonomic effects using continuous IV infusion regimens and relate doses to acute safety and physiological measures.