Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy Subjects (2C-B)

Randomised, triple-masked, placebo-controlled, six-period cross-over study in healthy volunteers comparing single oral doses of 2C-B (10, 20, 30 mg), MDMA (125 mg), psilocybin (25 mg) and placebo.

Aims are to characterise acute subjective, physiological and endocrine profiles and to compare empathogenic and classic psychedelic effects within the same subjects for basic science purposes.

Subjective effects peak 1–2 hours and are reported to last about 5 hours; outcomes include subjective ratings, vitals and endocrine measures.