Acute Effects of R- and S-MDMA in Healthy Subjects (R-S-MDMA)

Randomised, double-blind, triple-masked, five-period crossover in healthy volunteers comparing 125 mg racemic MDMA, 125 mg S-MDMA, 125 mg R-MDMA, 250 mg R-MDMA, and placebo.

Primary aim is basic science: to characterise acute subjective, physiological and neuroendocrine differences between enantiomers and racemate; participants abstain from psychoactives and follow protocol restrictions.