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Antidepressant Response of DMT Masked With Propofol (DMT4D)

Not yet recruitingRegisteredCTG

This randomised, placebo-controlled, quadruple-masked trial (n=112) will investigate whether the antidepressant effects of DMT (2 mg/min over 20 minutes; total ~40 mg) in patients with MDD depend on the subjective psychedelic experience by comparing DMT vs placebo under propofol sedation or no sedation.

Details

This 2x2 factorial randomized trial compares DMT infusion to placebo, each administered with or without propofol sedation, to determine whether antidepressant effects require the subjective psychedelic experience.

Outcomes include depressive symptom change (MADRS), measures of neuroplasticity and inflammation, safety and adverse events; participants receive a single 20-minute infusion (2 mg/min) with follow-up assessments.

Topics:Major Depressive Disorder (MDD)

Registry

Registry linkNCT06927076