Beyond the Self and Back: Neuropharmacological Mechanisms Underlying the Dissolution of the Self

Four placebo-controlled, double-blind study groups test single oral doses of psilocybin to characterise neural, behavioural and phenomenological aspects of self-related processes across EEG, fMRI and biological measures.

Groups 1–3 are healthy volunteer cohorts (EEG or fMRI) and Group 4 compares long-term and novice meditators during a 5-day retreat; outcomes include neuroimaging, psychometrics and blood/saliva biomarkers.