Prospective double-blind placebo-controlled RCT (Shenzhen Maternity and Child Healthcare Hospital) testing whether a single intra-operative bolus of ketamine 0.25 mg/kg IV (vs 0.9% saline) after umbilical cord clamping during elective caesarean section reduces postpartum depression. Enrolled: 330 ASA I–II parturients (screened 448, analysed 325). Primary outcome: EPDS at 3 days and 6 weeks postpartum. Secondary: NRS pain. Conducted October 2015 – March 2016.
Intravenous ketamine (0.25 mg/kg diluted to 10 mL with 0.9% saline) administered within 5 min following clamping of the neonatal umbilical cord.
diluted to 10 mL with 0.9% saline
Intravenous 10 mL of 0.9% saline administered within 5 min following clamping of the neonatal umbilical cord.
10 mL of 0.9% saline