Circulating Oxytocin Changes in Response to the Oxytocin System Stimulator MDMA in Patients With Diabetes Insipidus and Healthy Controls

Randomized, double-blind, placebo-controlled crossover study comparing single 100 mg MDMA versus placebo in 30 participants (patients with central diabetes insipidus and matched healthy volunteers) to measure acute changes in circulating oxytocin.

Primary purpose is basic science; MDMA administered as gelatin capsule with mannitol filler. Outcomes include plasma oxytocin response; standard safety exclusions applied (cardiovascular disease, psychiatric disorders, interacting medications).