Cognitive Behavioral Therapy in Prolonging the Antidepressant Effects of Intravenous Ketamine

Twelve to sixteen subjects with current depressive episodes receive a course of four intravenous ketamine infusions administered twice weekly over two weeks combined with structured cognitive behavioural therapy beginning the day after the first infusion.

CBT comprises 16 sessions over eight weeks delivered by a Beck Institute-trained therapist; primary outcomes focus on antidepressant response and durability following ketamine.