Does Psilocybin Change Synaptic Density in Amnestic Mild Cognitive Impairment

Randomised, quadruple-blind, parallel-group Phase II study (n=60; 30 aMCI, 30 healthy controls) comparing two 25 mg oral doses of psilocybin separated by one week versus two placebo doses.

Primary outcome is change in synaptic vesicular density measured with 18F-SynVesT-1 PET before and one week after the last dose; additional PET with [18F]T807 for tau, and cognitive testing at 1, 4, and 12 weeks.