Does Serotonin System Stimulation Increase Pro-social Behavior? – A Comparative Pharmacological Neuroscientific Study in Healthy Humans
This Phase I intervention trial (n=120) investigates whether stimulating the serotonin system influences pro-social behaviour compared to stimulating the dopamine system in healthy individuals; single-dose psilocybin (15 mg), MDMA (100 mg) or methylphenidate (60 mg) in a double-blind randomized parallel design.
Details
Randomized, double-blind, single-center, parallel-group Phase I study in healthy volunteers comparing single doses of psilocybin (15 mg), MDMA (100 mg) and methylphenidate (60 mg) to investigate pro-social cognition.
Objective, ecologically valid measures of pro-social behaviour will be assessed acutely and at four weeks to determine lasting and pharmacology-specific effects; safety and tolerability monitored by standard clinical and laboratory measures.