Dose Low Dose Ketamine in Casesarian
Prospective case-control observational study (n=150) comparing single-dose IV ketamine (0.5 mg/kg), ketamine plus midazolam, and saline placebo in patients undergoing caesarean section to evaluate postpartum depression and postoperative outcomes.
Details
This prospective case-control study will allocate 150 patients undergoing caesarean section under spinal anaesthesia into three groups: ketamine 0.5 mg/kg IV, midazolam pre-dose followed by ketamine 0.5 mg/kg IV, or 5 ml IV saline placebo.
Postpartum depression will be assessed with the Edinburgh Postpartum Depression Scale (EPDS) preoperatively and at 1, 2 and 4 weeks post partum; secondary outcomes include analgesic requirement and adverse effects such as dizziness, hallucinations, nausea and vomiting.