This double-blind, placebo-controlled crossover trial (n=30) investigated the effects of MDMA (100mg) compared to placebo on feelings of closeness and mood in semi-structured dyadic conversations.
Paired-partner, within-subject design with three sessions: MDMA+conversation with Person A, placebo+conversation with Person B, and a post-test online session assessing partner preference; drug/placebo order counterbalanced and partners same-sex.
Primary outcomes are self-rated feelings of closeness and connection after each drug session and at the online test; participants are fully debriefed after study completion.
Within-subject crossover: MDMA (100 mg) and placebo in counterbalanced order; 45-min semi-structured dyadic conversation.
Single 100 mg oral MDMA session; order counterbalanced.
Placebo lactose capsule.