Effect of Esketamine on Conscious State in Patients With pDoC
Randomised, quadruple-blind, parallel-group trial (n=116) assessing intraoperative IV esketamine 0.3 mg/kg versus saline on consciousness measures in patients with prolonged disorders of consciousness undergoing surgery under sevoflurane anaesthesia.
Details
This parallel, randomised, quadruple-blind study will compare a single intraoperative IV infusion of subanaesthetic esketamine (0.3 mg/kg over 30 minutes) to matched normal saline in patients with prolonged disorders of consciousness undergoing surgery under sevoflurane anaesthesia.
Primary and secondary assessments include Coma Recovery Scale–Revised, Glasgow Coma Scale, Full Outline of UnResponsiveness scores, SedLine multichannel EEG measures and perioperative adverse events; outcomes measured acutely and in the perioperative period.