Double-blind, randomised, controlled perioperative trial (n=200) evaluating a single subanesthetic esketamine dose to reduce postoperative anxiety and depression in adolescents undergoing elective surgery.
Prospective, double-blind, randomised, parallel-group trial in adolescents undergoing elective surgery; esketamine given shortly before incision versus normal saline.
Outcomes include postoperative incidence and severity of anxiety and depression, perioperative vital signs, and inflammatory markers (IL-6, CRP) collected during surgery.
Single perioperative subanesthetic esketamine dose given before surgery.
Given 5 minutes before procedure; registry text also lists 0.25 mg/kg in another place.
Normal saline, same volume as esketamine.
Normal saline, same volume as active.