Effect of Esketamine on Reducing Postoperative Anxiety and Depression in Adolescent Patients

Prospective, double-blind, randomised, parallel-group trial in adolescents undergoing elective surgery; esketamine given shortly before incision versus normal saline.

Outcomes include postoperative incidence and severity of anxiety and depression, perioperative vital signs, and inflammatory markers (IL-6, CRP) collected during surgery.