Effect of Ketamine in Depressive Symptoms of Elderly Patients With Visual Impairment

Depression in older adults is common and associated with worse medical comorbidity and quality of life. This study evaluated the effect of a single ketamine infusion (0.5 mg/kg) on depressive symptoms in patients aged 60+ undergoing ophthalmologic surgery.

Randomised, double-blind, parallel design (n=90) comparing ketamine 0.5 mg/kg IV given as a slow 2-hour infusion to 0.9% saline. Depressive symptoms were measured with the abbreviated Geriatric Depression Scale (Yesavage) at baseline, recovery end, and 24 hours post-surgery.