Randomised, double-blind, parallel trial (n=90) testing a single 0.5 mg/kg IV ketamine infusion over 2 hours versus saline in patients aged ≥60 undergoing ophthalmologic surgery to assess depressive symptoms.
Depression in older adults is common and associated with worse medical comorbidity and quality of life. This study evaluated the effect of a single ketamine infusion (0.5 mg/kg) on depressive symptoms in patients aged 60+ undergoing ophthalmologic surgery.
Randomised, double-blind, parallel design (n=90) comparing ketamine 0.5 mg/kg IV given as a slow 2-hour infusion to 0.9% saline. Depressive symptoms were measured with the abbreviated Geriatric Depression Scale (Yesavage) at baseline, recovery end, and 24 hours post-surgery.
Single IV infusion 0.5 mg/kg over 2 hours
Slow infusion over 2 hours
0.9% saline matched to ketamine solution (sham comparator)
0.9% saline, matched physical characteristics