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Effect of Methylenedioxymethamphetamine (MDMA) (Serotonin Release) on Fear Extinction

CompletedResults publishedRegisteredCTG

The primary aim of this study is to investigate the role of acute serotonin release in the effects of fear extinction. MDMA will be used as pharmacological tool to induce serotonin release in this study.

Details

Double-blind, randomised, within-subject crossover in healthy male volunteers (n=30) comparing a single oral dose of MDMA 125 mg with matching placebo to assess effects on fear extinction.

Primary purpose is basic science: using MDMA as a pharmacological tool to induce acute serotonin release and examine its role in fear conditioning and extinction; outcomes include behavioural extinction measures and related psychophysiology.

Topics:Healthy Volunteers

Registry

Registry linkNCT03527316