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Effect of the Addition of Ketamine to Sevoflurane Anesthesia in Electroconvulsive Therapy

Unknown statusRegisteredCTG

Randomised, double-blind, parallel-group Phase IV trial (n=60) comparing adjunctive IV ketamine 0.5 mg/kg versus saline combined with sevoflurane induction during ECT in patients with major depression.

Details

Parallel-group randomised trial comparing sevoflurane induction plus a single IV bolus of ketamine 0.5 mg/kg versus sevoflurane plus saline during ECT; groups described as Group SK and Group SS.

Primary measurements include motor and EEG seizure durations and haemodynamic responses (MAP and HR) recorded at baseline, post-induction, and at 0, 1, 3 and 10 minutes after seizure end.

Topics:Major Depressive Disorder (MDD)

Registry

Registry linkNCT02267980