Randomised, double-blind, parallel-group Phase IV trial (n=60) comparing adjunctive IV ketamine 0.5 mg/kg versus saline combined with sevoflurane induction during ECT in patients with major depression.
Parallel-group randomised trial comparing sevoflurane induction plus a single IV bolus of ketamine 0.5 mg/kg versus sevoflurane plus saline during ECT; groups described as Group SK and Group SS.
Primary measurements include motor and EEG seizure durations and haemodynamic responses (MAP and HR) recorded at baseline, post-induction, and at 0, 1, 3 and 10 minutes after seizure end.
Sevoflurane induction (8% until loss of consciousness) followed by IV ketamine 0.5 mg/kg bolus (Group SK; n≈29).
IV bolus 0.5 mg/kg given after induction
Sevoflurane 8% for induction until loss of consciousness, then discontinued
Sevoflurane induction (8% until loss of consciousness) followed by IV saline placebo bolus (Group SS; n≈30).
Sevoflurane 8% for induction until loss of consciousness, then discontinued
Isotonic saline IV bolus as placebo