Randomised, double-blind, placebo-controlled ED trial (n=29) testing a single low-dose IV ketamine infusion (0.5 mg/kg over 40 minutes) for acute depression or suicidal ideation.
This randomised, quadruple-blind, parallel-group trial compares a single low-dose ketamine infusion (0.5 mg/kg) with placebo in adults presenting to the emergency department with severe depression or suicidal ideation.
Patients are identified at triage or intake, assessed for eligibility, and randomised by computer to ketamine or saline. The study drug is given as a 50 mL IV infusion over 40 minutes with observation and psychiatric reassessment four hours after infusion.
Primary outcomes assess change in depression symptoms during the ED visit and healthcare utilisation after discharge; follow-up contact occurs 30 days after leaving hospital.
Single IV infusion of ketamine 0.5 mg/kg in 50 mL 0.9% saline over 40 minutes.
0.5 mg/kg (Ketalar) in 50 mL 0.9% saline given over 40 minutes; observation and reassessment for 4 hours post-infusion.
Normal saline 0.9% 50 mL IV infusion over 40 minutes.
0.9% sodium chloride 50 mL IV over 40 minutes (placebo comparator).