Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department
Randomised, double-blind, placebo-controlled ED trial (n=29) testing a single low-dose IV ketamine infusion (0.5 mg/kg over 40 minutes) for acute depression or suicidal ideation.
Details
This randomised, quadruple-blind, parallel-group trial compares a single low-dose ketamine infusion (0.5 mg/kg) with placebo in adults presenting to the emergency department with severe depression or suicidal ideation.
Patients are identified at triage or intake, assessed for eligibility, and randomised by computer to ketamine or saline. The study drug is given as a 50 mL IV infusion over 40 minutes with observation and psychiatric reassessment four hours after infusion.
Primary outcomes assess change in depression symptoms during the ED visit and healthcare utilisation after discharge; follow-up contact occurs 30 days after leaving hospital.