Effects of Dimethyltryptamine in Healthy Subjects

This randomised, quadruple-blind, five-period crossover study in healthy volunteers compares four intravenous DMT administration schemes and placebo using a bolus and maintenance perfusion model to produce a stable, prolonged DMT experience.

Primary aims are to test dose–response relationships and to compare bolus-plus-perfusion versus perfusion-only schedules on pharmacokinetic, subjective and autonomic outcomes; safety and tolerability are systematically recorded.