Crossover within-subject study (n=30) in healthy volunteers comparing single oral MDMA (75 mg), methylphenidate (40 mg), and placebo to assess effects on emotional and social cognition.
Randomised allocation not specified; crossover within-subject design with three single-dose conditions (MDMA 75 mg, methylphenidate 40 mg, placebo) administered on separate sessions to healthy adult volunteers.
Primary aim is basic science: to compare effects on affective perception and social cognition; outcomes include behavioural tests of emotional and social processing and safety/tolerability monitoring.
Crossover within-subject design with three treatment conditions (MDMA, methylphenidate, placebo) tested in each subject.
Single 75 mg oral dose.
Methylphenidate 40 mg (active comparator) — recorded as non-listed compound; name/dose in notes.
Placebo capsules matching MDMA or methylphenidate.