This completed double-blind, placebo-controlled trial (n=24) aimed to investigate the effects of co-administering MDMA with LSD in healthy subjects. The study, conducted by the University Hospital in Basel, Switzerland, assessed the acute subjective and autonomic effects of LSD alone and in combination with MDMA.
Rationale: MDMA reliably increases positive mood, empathy and trust and may reduce anxiety during classic psychedelic (LSD) experiences; this study tested whether MDMA coadministration improves the subjective valence and autonomic profile of LSD in healthy volunteers.
Design: Randomized, triple-masked, double-blind, 4-period crossover (100 µg LSD and 100 mg MDMA in all combinations versus double placebo) assessing acute subjective and autonomic outcomes in 24 healthy adults.
100 µg LSD with MDMA placebo (single dose).
MDMA placebo (mannitol)
100 mg MDMA with LSD placebo (single dose).
LSD placebo (alcohol solution)
100 µg LSD with 100 mg MDMA (single dose).
Double placebo comparator (LSD placebo + MDMA placebo).
LSD placebo (alcohol solution)
MDMA placebo (mannitol)