Effects of MDMA on Social and Emotional Processing

Randomised allocation was not used; this is a within-subjects, double-blind, double-dummy experiment in healthy volunteers (n=65) comparing two active MDMA doses, oxytocin 20 IU, and placebo to characterise empathogenic effects.

Primary measures assess emotion recognition, emotional responsiveness and sociability; safety monitoring included ECG and medical screening. MDMA dosing used 0.75 and 1.5 mg/kg (capped at 125 mg).