Randomised, quadruple-blind, placebo-controlled crossover fMRI study (n=24) administering single doses of methylphenidate 60 mg, modafinil 600 mg, MDMA 125 mg, and placebo to healthy volunteers to assess emotion-processing and cognitive performance.
This placebo-controlled, randomized crossover study enrolled 24 healthy adult volunteers to compare single oral doses of methylphenidate (60 mg), modafinil (600 mg), MDMA (125 mg) and placebo during fMRI to assess drug-specific effects on emotion-processing and social cognition.
Outcomes include task-based fMRI measures of emotion processing, subjective emotional effects and sociability, neurohormonal and cardiovascular responses, and plasma drug concentrations; participants completed separate single-dose sessions with washout between conditions.
Within-subject, randomized, placebo-controlled crossover with four single-dose conditions (methylphenidate, modafinil, MDMA, placebo).
Methylphenidate (single 60 mg)
Modafinil (single 600 mg)
MDMA (single 125 mg)
Placebo capsules matching active drugs