Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought

This double-blind, placebo-controlled, within-subject crossover study in healthy volunteers uses EEG and MRI during cognitive tasks and naturalistic stimuli to examine acute effects of psilocybin (10 mg/70 kg) on thought dynamics, creativity, memory, and shared versus individual brain responses.

Psilocybin and matching placebo are administered as size 0 blue gelatin capsules; sessions last approximately 6 hours with a washout between visits. Primary outcomes include electrophysiological measures, MRI responses, and behavioural task performance.