Randomised, crossover study (n=30) comparing 15 mg oral psilocybin with placebo in healthy volunteers to assess effects on brain synchrony and cognition during film viewing.
This randomized, two-session crossover study in healthy volunteers tests whether 15 mg oral psilocybin alters inter-subject brain synchrony measured with fMRI while participants watch film clips, perform mental imagery tasks, and listen to music.
Each participant completes one psilocybin and one placebo scanning session at least two weeks apart; cognitive testing, questionnaires on plot comprehension and subjective experience, visual illusion tasks and web-based cognitive games follow scans.
The study aims to inform neuroimaging methods for detecting awareness in disorders of consciousness by determining whether psilocybin modulates brain synchrony during shared stimulus exposure.
Receive 15 mg oral psilocybin in first scanning session, placebo in second (≥2 week washout).
15 mg oral psilocybin given prior to fMRI session.
Oral placebo given in alternate session.
Receive placebo in first scanning session, 15 mg oral psilocybin in second (≥2 week washout).
Oral placebo given in first session.
15 mg oral psilocybin given in second session.