Effects of Subanesthetic Dose of Ketamine Given on Postoperative Mood in Patients Undergoing Fractional Curettage

Randomised, triple-masked, parallel-group trial (n=140) comparing a single IV 0.5 mg/kg ketamine dose given at induction versus 0.9% saline placebo in women undergoing fractional curettage; primary outcome acute mood (POMS) before discharge.

Secondary measures include pain, sedation, blood pressure and heart rate, and adverse events; key exclusions were pregnancy, uncontrolled hypertension, seizure disorders, substance abuse and major medical disease.