This randomized controlled trial (n=140) investigated the impact of a single subanesthetic dose of ketamine (35mg/70kg) administered intravenously during the induction of propofol/fentanyl anesthesia on acute mood states in women undergoing fractional curettage.
Randomised, triple-masked, parallel-group trial (n=140) comparing a single IV 0.5 mg/kg ketamine dose given at induction versus 0.9% saline placebo in women undergoing fractional curettage; primary outcome acute mood (POMS) before discharge.
Secondary measures include pain, sedation, blood pressure and heart rate, and adverse events; key exclusions were pregnancy, uncontrolled hypertension, seizure disorders, substance abuse and major medical disease.
Single IV 0.5 mg/kg ketamine at induction with propofol/fentanyl
Given at induction with propofol/fentanyl
0.09% saline 0.05 ml/kg IV at induction with propofol/fentanyl
0.05 ml/kg 0.9% saline