Randomised, double-blind, placebo-controlled crossover in 16 healthy volunteers comparing single oral MDMA 125 mg with and without methylphenidate 60 mg (administered 1 h pre-dose).
Randomised, double‑blind, placebo‑controlled crossover study in 16 healthy volunteers testing the role of dopamine and norepinephrine transporter blockade (methylphenidate 60 mg) on the subjective and cardiovascular effects of a single oral MDMA dose (125 mg).
Subjective and cardiovascular measures were repeatedly assessed throughout four experimental sessions; plasma samples were collected for pharmacokinetics. The primary aim was to determine whether methylphenidate attenuates MDMA’s subjective effects.
Randomised, double-blind, placebo-controlled crossover with four within-subject conditions (MDMA, MDMA+MPH, MPH, placebo).
Single oral dose (125 mg).
Methylphenidate 60 mg PO given 1 hour before MDMA/placebo.
Capsules identical to MDMA or methylphenidate (placebo).