Emotional Effects of Methylphenidate and MDMA in Healthy Subjects

Randomised, double‑blind, placebo‑controlled crossover study in 16 healthy volunteers testing the role of dopamine and norepinephrine transporter blockade (methylphenidate 60 mg) on the subjective and cardiovascular effects of a single oral MDMA dose (125 mg).

Subjective and cardiovascular measures were repeatedly assessed throughout four experimental sessions; plasma samples were collected for pharmacokinetics. The primary aim was to determine whether methylphenidate attenuates MDMA’s subjective effects.