Epigenetics and MDMA-Assisted Psychotherapy for PTSD

This substudy collects saliva from participants enrolled in the parent Phase III randomized trial of MDMA-assisted psychotherapy to evaluate whether treatment-related changes occur in the epigenetic regulation of stress-associated genes.

Saliva is collected at baseline (prior to the first experimental session) and following the final experimental session (approximately 18 weeks after the first treatment) using Oragene DNA OG-500 kits for downstream analysis of salivary epithelial and white blood cell DNA.