Esketamine on Postpartum Depression in Cesarean Section Women

This randomised, quadruple-blind, parallel trial evaluates whether a single IV bolus of esketamine (0.25 mg/kg) given 15 minutes after umbilical cord amputation, together with an esketamine-containing PCIA (80 mg esketamine + sufentanil 100 µg), reduces incidence of postpartum depression compared with saline and standard PCIA.

Primary outcome is incidence of PPD assessed by EPDS at 7, 30, 60 and 90 days (EPDS ≥10). Safety and tolerability are monitored intraoperatively and during postpartum follow-up.