Clinical TrialImplementation & Service DeliveryMDMAPlaceboRecruiting

Evaluating the atittudes of Australian psychologists, psychiatrists and mental health researchers towards 3,4-Methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for the treatment of PTSD: A double-blind, randomised controlled trial

This double-blind, randomised controlled trial (n=200) aims to evaluate the attitudes of Australian psychologists, psychiatrists, and mental health researchers towards MDMA-assisted psychotherapy for the treatment of PTSD.

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Target Enrollment
100 participants
Study Type
Phase NA interventional
Design
Randomized, single Blind

Detailed Description

Online, parallel-group randomized vignette study recruiting Australian psychologists, psychiatrists and mental health researchers who read a single vignette describing a hypothetical Phase 3 trial of either MDMA-assisted psychotherapy or a fabricated drug (JB-4801) plus psychotherapy.

Participants complete a ~10-minute survey (one timepoint between February and November 2020) with outcomes including subjective safety concern (10-point Likert) and predicted efficacy (10-point Likert). No direct contact or actual drug administration occurs.

Study Protocol

Preparation

sessions

Dosing

sessions

Integration

sessions

Therapeutic Protocol

Manualized psychotherapy included

Study Arms & Interventions

MDMA vignette

experimental

Online vignette describing MDMA-assisted psychotherapy (hypothetical Phase 3 trial).

Interventions

  • MDMA

    Participant reads a vignette describing MDMA-assisted psychotherapy; no actual dosing.

JB-4801 vignette

active

Online vignette describing a fabricated JB-4801-assisted psychotherapy (control).

Interventions

  • Placebo

    Fabricated compound 'JB-4801' used in vignette to avoid prior beliefs; no actual dosing.

Participants

Ages
18 – 98
Sexes
Male & Female

Inclusion Criteria

  • Participants must be working within Australia as a psychologist, psychiatrist or mental health researcher.
  • Psychologists and psychiatrists must be registered with AHPRA.

Exclusion Criteria

  • People under the age of 18.
  • People who do not work in Australia.

Study Protocol, Arms & Participants

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Study Details

Locations

Unknown facility — Australia

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