Evaluation of MDMA on Startle Response

Randomized, double-blind, parallel-group Phase I trial in healthy volunteers comparing a single oral 100 mg MDMA dose to inactive placebo; acoustic startle testing occurs at baseline, after dosing (Visit 2) and at a follow-up (Visit 3).

Outcomes include startle magnitude (orbicularis oculi EMG), vitals and repeated blood sampling for oxytocin and exploratory biomarkers; sleep is tracked by self-report and Fitbit, and participants complete experience questionnaires.