Examining The Effect Of Ketamine On Glutamate/Glutamine Cycling

Randomised status: non-randomised, crossover design for mechanistic/basic-science purposes; 36 actual participants including healthy controls and participants with MDD receiving ketamine during magnetic resonance scans.

Primary outcomes assess ketamine effects on glutamate/glutamine cycling using 13C‑MRS alongside behavioural measures (MADRS, QIDS-SR16) and safety screening; exclusion criteria include active substance dependence, serious medical/neurological illness, pregnancy, and significant suicidality.