Clinical TrialAlcohol Use Disorder (AUD)DMTCompleted

DPT-Assisted Psychedelic-Peak Psychotherapy for Alcoholism: An Open Clinical Study (Grof 1973, Spring Grove State Hospital)

Exploratory, open clinical study (International Pharmacopsychiatry 1973; Grof S, Soskin RA, Richards WA, Kurland AA; Spring Grove State Hospital, Baltimore, MD, USA). Participants: 51 alcoholic patients drawn from the Alcoholic Rehabilitation Unit of Spring Grove State Hospital, selected by medical and psychiatric screening for suitability for psychedelic-peak therapy. Exclusions included organic brain damage, epilepsy, active renal or hepatic disease, and other specified contraindications. Intervention: dipropyltryptamine (DPT), a synthetic short-acting psychedelic, administered as an adjunct to psychotherapy in a psychedelic-peak therapy framework. No control arm; open-label exploratory design. Outcomes: clinical and psychotherapeutic change in alcoholism. No trial registry; pre-dates any formal registration requirement by ~32 years.

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Target Enrollment
51 participants
Study Type
Phase NA interventional
Design
Non-randomized

Detailed Description

This synthetic trial has been added to our database because a psychedelic paper (about a clinical trial) references this trial, but no (live) registration can be found.

The study investigated the efficacy of dipropyltryptamine (DPT) administered intramuscularly as an adjunct to psychedelic-peak psychotherapy for individuals suffering from alcoholism. Participants were recruited from the Alcoholic Rehabilitation Unit at Spring Grove State Hospital and underwent medical and psychiatric screening to ensure suitability for the intervention.

Outcomes were measured using a comprehensive battery of psychological tests, including the Minnesota Multiphasic Personality Inventory (MMPI) and the Personal Orientation Inventory (POI), alongside assessments of residential, occupational, and interpersonal adjustment. Follow-up evaluations were conducted by an independent team of social workers to monitor abstinence and global adjustment.

Study Arms & Interventions

High-dose DPT

experimental

High doses of DPT (60-150 mg) administered intramuscularly as an adjunct to psychotherapy.

Interventions

  • DMT105 mg
    via IM• single dose• 1 doses total

    Dose range 60-150 mg; sessions lasted 4-6 h; average 1.86 sessions per patient.

Study Details

  • Status
    Completed
  • Phase
    Phase NA
  • Type
    interventional
  • Design
    Non-randomized
  • Target Enrollment51 participants
  • Timeline
    Start: 1970-01-01
    End: 1973-01-01
  • Compound
    DMT
  • Topic
    Alcohol Use Disorder (AUD)

Locations

United States

Related Publications

PaywallindividualPrimary

DPT as an adjunct in psychotherapy of alcoholics

This early study (1973; n=51) investigated the use of DPT (tryptamine psychedelics) in combination with therapy for the treatment of alcoholism (AUD). At the six-month follow-up, 38% of participants stayed completely abstinent, about 50% were classified as rehabilitated.

Published
Journal
Pharmacopsychiatry
Authors
Grof, S., Soskin, R. A., Richards, W. A., Kurland, A. A.