Clinical TrialAlcohol Use Disorder (AUD)DMTCompleted

DPT-Assisted Psychedelic-Peak Psychotherapy for Alcoholism: An Open Clinical Study (Grof 1973, Spring Grove State Hospital)

Exploratory, open clinical study (International Pharmacopsychiatry 1973; Grof S, Soskin RA, Richards WA, Kurland AA; Spring Grove State Hospital, Baltimore, MD, USA). Participants: 51 alcoholic patients drawn from the Alcoholic Rehabilitation Unit of Spring Grove State Hospital, selected by medical and psychiatric screening for suitability for psychedelic-peak therapy. Exclusions included organic brain damage, epilepsy, active renal or hepatic disease, and other specified contraindications. Intervention: dipropyltryptamine (DPT), a synthetic short-acting psychedelic, administered as an adjunct to psychotherapy in a psychedelic-peak therapy framework. No control arm; open-label exploratory design. Outcomes: clinical and psychotherapeutic change in alcoholism. No trial registry; pre-dates any formal registration requirement by ~32 years.

Target Enrollment
51 participants
Study Type
Phase NA interventional
Design
Non-randomized

Study Arms & Interventions

High-dose DPT

experimental

High doses of DPT (60-150 mg) administered intramuscularly as an adjunct to psychotherapy.

Interventions

  • DMT105 mg
    via IM• single dose• 1 doses total

    Dose range 60-150 mg; sessions lasted 4-6 h; average 1.86 sessions per patient.

Primary Results(1 publication)

Participants

N = 51Mean age: 38.6 across armsS. et al. 1973 →

Response Rates

Score of 8, 9, or 10 on 0-10-point scale of the social history questionnaire

25/47(53.2%)·S. et al. 1973 →
22/47(46.8%)·S. et al. 1973 →

Totally abstinent (score of 10) on 0-10-point scale of the social history questionnaire

18/47(38.3%)·S. et al. 1973 →

Adverse Events (from all publications)

Arm / GroupnAny TEAESevereSeriousDiscont.
High-dose DPTexperimental51——1(2.0%)—

* One patient experienced a brief psychotic episode 3 weeks after the last administration, requiring readmission and treatment with a tranquillizer (Mellaril). The authors noted this might be related to DPT or other factors like fasting/sleep deprivation.

Study Details

  • Status
    Completed
  • Phase
    Phase NA
  • Type
    interventional
  • Design
    Non-randomized
  • Target Enrollment51 participants
  • Timeline
    Start: 1970-01-01
    End: 1973-01-01
  • Compound
    DMT
  • Topic
    Alcohol Use Disorder (AUD)

Related Publications

DPT as an adjunct in psychotherapy of alcoholics

Published
Authors
Grof, S., Soskin, R. A., Richards, W. A., Kurland, A. A.

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