Imaging Neural Correlates of Ketamine Using PET/MR

This is a randomized, double-blind, placebo-controlled crossover study using [18F]FDG PET/MR to compare pharmacodynamic effects of intravenous racemic ketamine and esketamine in healthy adult volunteers.

The protocol includes pilot studies: a pilot for pharmacokinetics/acute behavioural effects and a Pilot II of 15 healthy volunteers to optimise scanning procedures (two-scan crossover). The main study uses a three-scan schedule with placebo at first scan and active drug at subsequent scans in crossover assignment.