Imaging SV2A in Mood Disorders — Clinical Trial Details | Blossom

Imaging SV2A in Mood Disorders — Clinical Trial Details | Blossom

Participants

Ages

18 – 70

Sexes

Male & Female

BMI

-

Psychosis History

-

Inclusion Criteria

Inclusion Criteria:
General inclusion criteria:
1. Subjects will be 18-70 years old.
2. English speaking.
3. No other DSM-5 diagnosis present, besides required as below.
Depressed subjects:
1. Meet DSM-5 diagnostic criteria for Major Depressive Disorder and for a current depressive episode.
2. Treatment- or non-treatment-seeking who understand this study is for research purposes only.
Healthy controls:
1. No current or history of any DSM-5 diagnosis.
PTSD subjects:
1. Current Post Traumatic Stress Disorder.
Bipolar subjects:
1. Meet DSM-5 diagnostic criteria for bipolar disorder.
Subjects undergoing ketamine treatment:
1. Meet DSM-5 criteria for MDD/current depressive episode and are undergoing ketamine treatment.

Exclusion Criteria

Exclusion Criteria:
1. Significant medical illness contraindicating participation.
2. Lifetime history of neurologic abnormality including seizure disorder, cerebrovascular/neoplastic lesion, neurodegenerative disorder, or significant head trauma with post-traumatic amnesia >24 hours.
3. Full scale IQ <70.
4. Contraindication to MRI (e.g., claustrophobia, ferromagnetic object, orthodontic braces).
5. Pregnancy or breastfeeding.
6. Met DSM-5 criteria for mild SUD (except nicotine and marijuana) within past 6 months or moderate–severe SUD within past year.
7. Claustrophobia.
8. Current psychosis, active suicidal or homicidal ideation.
9. Positive urine toxicology screen (except marijuana).
10. Contraindications to PET (e.g., past/current cancer, poor venous access).
11. Prior research radiation exposure within past year placing subject over FDA annual limits.
12. Occupational radiation exposure within one year that precludes participation.
13. Blood pressure >130/80 (for ketamine challenge); BP >140/90 (non-ketamine groups).
14. Arterial line exclusions: bleeding disorder or anticoagulant use.
15. Arterial line exclusion: blood donation within eight weeks of study start.
16. Current diagnosis of MDD or PTSD with psychotic features.
17. Hematocrit <35 mg/dl or hemoglobin <10 mg/dl.
18. Weight under 110 lbs for certain blood-draw portions of the study.