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Influence of Bupropion on the Effects of MDMA

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The purpose of this study is to determinate the effect of a pre-treatment with bupropion, a dopamine and norepinephrine transporter inhibitor, on the pharmacodynamics and pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”). The study will provide further understanding of the dopaminergic regulation of mood.

Details

Randomised, double-blind, placebo-controlled crossover in 16 healthy volunteers testing the effect of bupropion pre-treatment on acute physiological and subjective responses to MDMA.

Bupropion XR given for 7 days (150 mg x3 days, then 300 mg x4 days) with a single 300 mg dose 2 hours before MDMA 125 mg or placebo; outcomes include repeated subjective measures, cardiovascular responses, and MDMA pharmacokinetics.

Topics:Healthy Volunteers

Registry

Registry linkNCT01771874