Interaction Between Duloxetine and 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy)

Healthy volunteers undergo four experimental sessions in a randomised double-blind crossover comparing duloxetine 120 mg (two pre-doses) or placebo with MDMA 125 mg or placebo; subjective, cardiovascular and plasma PK measures are collected repeatedly.

Primary aim is to determine whether combined 5-HT and NE reuptake inhibition by duloxetine attenuates MDMA-induced subjective and cardiovascular effects and alters MDMA pharmacokinetics.