Intravenous Ketamine Plus Neurocognitive Training for Depression
Randomized, parallel-group study (n=154 actual) testing intravenous subanesthetic ketamine with or without adjunctive computer-based cognitive training for treatment-resistant depression; mechanistic outcomes (fMRI, IAT, cognitive flexibility) and clinical outcomes (MADRS acute; QIDS over 12-month follow-up).
Details
This randomized, quadruple-masked, parallel-group trial examines whether pairing subanesthetic intravenous ketamine with computer-based cognitive training extends antidepressant effects compared with ketamine with sham training and saline with training.
Aim 1 focuses on mechanistic outcomes (fMRI functional connectivity, Implicit Association Test, cognitive flexibility), and Aim 2 assesses clinical efficacy with MADRS during the acute 30-day phase and QIDS across a 12-month naturalistic follow-up.