Ketamine and Neurofeedback-Training: Effects on Neuroplasticity in Cocaine Addiction (Co-Boost)
This placebo-controlled, double-blind, parallel-group interventional trial (n=120) aims to explore the effects of combining ketamine with real-time functional magnetic resonance imaging (fMRI) neurofeedback training in individuals with cocaine use disorder (CUD).
Details
Randomized, placebo-controlled, double-blind, parallel-group single-centre study testing ketamine versus saline and active versus sham rt-fMRI neurofeedback in people with cocaine use disorder.
Participants receive a single i.v. infusion of ketamine (0.71 mg/kg over 40 minutes) or saline and undergo real-time fMRI neurofeedback or sham training (20-minute runs repeated three times).
Outcomes include percentage of cocaine use days, transfer effects of neurofeedback, and ketamine-dependent changes in nucleus accumbens glutamate measured by 1H-MRS; safety and tolerability also assessed.