Ketamine and Postoperative Depressive Symptom-PASSION

Randomized, parallel-group Phase II/III trial evaluating intraoperative IV ketamine (0.5 mg/kg over 40 minutes at dural opening) versus volume-matched normal saline in patients with supratentorial brain tumour and moderate–severe perioperative depressive symptoms.

Primary outcomes include change in depressive symptoms and safety of intraoperative ketamine; secondary outcomes include anxiety, postoperative pain, and delirium. Eighty-four participants were enrolled.